Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship.
نویسندگان
چکیده
منابع مشابه
Structure activity relationship in sixteen membered macrolide antibiotics.
Leucomycin (Kitasamycin) is a macrolide antibiotic having activity against gram-positive bacteria and certain Mycoplasma strains. Comparison of antimicrobial activities of the variuos leucomycin congeners (I-X) indicates a clear structure-activity relationship among them. The acylation of the 3-hydroxy group somewhat reduces the in vitro activity while the acylation of the 4"-hydroxy group of m...
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For clarification of the nature of the side effects of macrolide antibiotics on the gastrointestinal tract, the motor-stimulating activity of these agents was studied in unanesthetized dogs. The results showed that erythromycin and oleandomycin, the 14-membered macrolides with two side chain sugars combined at C3 and C5 in a glycosidic linkage in parallel, strongly stimulate gastrointestinal mo...
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The effect of four macrolide antibiotics (roxithromycin, clarithromycin, erythromycin, and azithromycin) on the generation of some mediators and cytokines involved in the inflammatory process has been studied both in vivo and in vitro. Rat carrageenin pleurisy was used as a model of acute inflammation, and the macrolides were administered (10, 20, and 40 mg/kg p.o.) 1 h before the carrageenin c...
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چکیده بررسی فعالیت ضد اکسیدانی و ضدمیکروبی عصاره گیاه بن سرخ (allium jesdianum) به کوشش: زهرا مقیمی هدف از این تحقیق بررسی میزان ترکیبات فنولی کل، ترکیبات فلاوونوئیدی کل، فعالیت ضداکسیدانی و ضدمیکروبی عصاره ی گیاه تازه و خشک بن سرخ بود. استخراج عصاره به روش های غوطه وری، استفاده از همزن مغناطیسی، دستگاه مایکروویو، امواج فراصوت و گرمادهی مقاومتی و با استفاده از متانول، اتانول و آب به عنوا...
Structure-activity relationship for the oxadiazole class of antibiotics.
The structure-activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure. This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding protein. They impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacter...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1985
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.38.1631